Consensus tips for contemporary shock management
• Early and frequent evaluation of the end-organ function, including measuring the lactate levels, may improve risk stratification and early diagnosis of CS; it also helps determine the requirement of advanced therapies and early invasive monitoring.
• Using a pulmonary artery catheter (PAC) early to assist in the diagnosis and management of CS may improve survival.
• Consider PAC in all patients on temporary mechanical circulatory support (tMCS).
Consensus tips for the management of CS in women
• It is advised to use PAC early in women in CS on vasopressors/inotropes, with rising lactate levels, persistent low cardiac output, and other signals of end-organ hypoperfusion; it should be used after assessing the device- and disease-specific risks and benefits.
Consensus tips for the treatment of acute myocardial infarction (AMI)-CS in women
• Early revascularization with percutaneous coronary intervention (PCI) and/or coronary artery bypass graft (CABG) is the main therapy in AMI-CS.
• It is appropriate to use tMCS support to recover and specific strategies for revascularization in high-risk lesions in patients with spontaneous coronary artery dissection (SCAD)-CS.
• It is reasonable to use Impella selectively and early (early or before in PCI) in women diagnosed with AMI-CS without coma.
• Routine use of intra-aortic balloon pump (IABP) or venoarterial extracorporeal membrane oxygenation (VA-ECMO) is not supported by the current evidence because of the increased risk of vascular complications and lack of mortality benefits.
Consensus tips for treatment of pregnant patients with CS, including PPCM
• It is important to have a multidisciplinary cardio-obstetrics team, comprising obstetricians, cardiologists, maternal fetal medicine specialists, anesthesiologists, critical care specialists, and nursing staff, to make immediate decisions in pregnant patients presented with CS; such patients are required to transfer to a center having a focused cardio-obstetrics program.
• Early invasive hemodynamic evaluation and considerations are crucial for maternal survival.
• It is important to take measures to reduce the exposure of the fetus to medications and radiation; however, it should not be the priority over treatments to save maternal life.
• It is preferred to use the bridge-to-recovery strategy in patients with peripartum cardiomyopathy–related cardiogenic shock (PPCM-CS) due to higher rates of at least partial recovery of the left ventricle.
Consensus tips for the treatment of heart failure–related cardiogenic shock (HF-CS) and use of advanced HF therapies in women
• Care pathways are needed to manage the treatment disparities in women with HF-CS. These pathways also ensure the timely and equal availability of durable left ventricular assist devices and heart transplantation.
• There is a need for clinical evidence to determine optimal timing and selection of tMCS in women with HF-CS.
Consensus tips to address barriers to care for women with CS
• Clinicians should not be deterred from using the potentially lifesaving tMCS because of expected vascular complications; mitigate the risk by implementing advanced vascular access techniques and following best practices for devices.
• Sex disparities in the CS outcomes may be reduced with a protocol focusing on standardized, team-based treatment of CS that may include mandatory assessment of hemodynamic status, timely diagnosis, and appropriate and early use of tMCS.