Catch Glucose Problems Early
Normal glucose tolerance can shift to diabetes or prediabetes fast. Early detection stops heart disease and full diabetes. Doctors need simple tests beyond fasting sugar. This study finds clear predictors after 5 years of watching patients. The study was published in the Diabetes Research and Clinical Practice.
Large Group Gets Full Testing
Researchers enrolled 1,008 Japanese adults with normal glucose tolerance at start. Everyone completed 75-g oral glucose tolerance test at baseline and after 5 years. Logistic regression tested predictors of glucose intolerance including diabetes or impaired fasting glucose
One-Hour Glucose Leads Risk
One-hour plasma glucose level during OGTT predicted glucose intolerance development best. Age interaction with 1-h PG made prediction stronger. Genetic factors worsened 1-h PG levels over time.
Age and Glucose Combo Strikes Hard
Patients with 1-h PG ≥8.3 mmol/L and age ≥57 years faced sex and BMI adjusted odds ratio of 12.9 with 95% CI 5.7-29.2 versus lower risk reference group. This combination flagged highest danger clearly.
Test One-Hour Levels Routinely
Add 1-h PG measurement to standard OGTT in normal patients over 50. Age 57 plus high 1-h PG demands immediate lifestyle changes. Genetics explain some progression but clinical measures guide action.
Screen Middle Age Patients First
Primary care doctors should order full OGTT not just HbA1c or fasting glucose. One-hour spike plus age predicts 13-fold risk jump. Early metformin or diet beats waiting for diabetes label.
Simple Combo Changes Practice
No fancy tests needed. Standard OGTT with age check identifies progressors. Findings apply across Asian and global populations likely.