CVD tops global death causes, with CKD as key risk amplifier. Amino acids form diet basics yet their role in CKD-CVD overlap stays underexplored. This review published in the Cardiovascular Research maps supplementation effects to spark prevention strategies.
Methods Synthesize Broad Evidence Base
Team searched PubMed and Web of Science for amino acid impacts on CKD-CVD comorbidities. They synthesized 60 papers: 13 clinical, 43 in vivo, 4 in vitro. Bias tools assessed quality. Studies split into preventive, harmful, or neutral effects by amino acid.
Results Highlight Preventive Potential
Of 60 studies, 43 showed preventive benefits, 18 adverse effects (3 both), and 2 neutral. Arginine led preventive findings across CVD-CKD markers. Methionine topped harmful reports, like vascular damage. Most data from animals limits human applicability.
Conclusions Push for Clinical Validation
Amino acids offer promise as CVD-CKD adjuncts, with arginine favoring prevention over methionine risks. Human trials must confirm translation from preclinical work. Targeted supplementation could fill therapy gaps in high-risk patients.
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Key highlights
- Review of 60 studies showed 43 reported preventive effects of amino acids on CKD-CVD comorbidities.
- Arginine demonstrated the highest number of preventive benefits across CVD and CKD markers.
- Methionine linked to the most adverse effects in the analyzed publications.
- Evidence included 13 clinical, 43 in vivo, and 4 in vitro studies, with bias assessed via standard tools.
- Further human clinical trials are essential to validate preclinical findings for patient use.
Source
Mikolajetz D, Kalim S, Noels H, et al. Impact of amino acid supplementation on cardiovascular and chronic kidney diseases: a systematic review. Cardiovasc Res. Published online January 21, 2026. Doi: https://doi.org/10.1093/cvr/cvag007
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Systematic review of 60 studies finds amino acids like arginine often prevent CKD-CVD comorbidities, while methionine shows most harms, urging human trials for therapy.
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