Trauma often leads to hospital stays in adults. Reactive hypertension occurs in these cases but lacks clear treatment data. Researchers tested if antihypertensive drugs affect hypotension, death, or stay length in musculoskeletal trauma patients without prior hypertension. The results were published in the Journal of Clinical Hypertension. 

This retrospective cohort used data from a Colombia high-complexity center, 2020-2024. It included adults >18 years with musculoskeletal trauma and two BP readings >140/90 mm Hg, no known hypertension. Groups split by antihypertensive treatment vs none (n=712). Logistic, linear, and time-to-event models checked hypotension needing intervention, in-hospital death, and length of stay.

Most were young men (77% male, mean age 35 years), low comorbidities (obesity 6.2%, diabetes 4.6%), 60% open fractures needing surgery. Treatment tied to higher hypotension odds (OR 11.9, 95% CI 5.69-26.4). No links to death (OR 5.18, 95% CI 0.79-39.6), stay length (1.5 days, 95% CI -0.1 to 3.1), or discharge time (HR 0.79, 95% CI 0.59-1.06) were reported.

In this trauma cohort, antihypertensive use associated with increased hypotension risk, without mortality or stay benefits. Cross-sectional elements highlight potential harm in reactive hypertension management.