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Youth with low bolus engagement achieved higher TIR when using one AID system compared with another. The analysis, published in Diabetes Care, evaluated glycemic outcomes among youth administering three or fewer boluses per day.

The study included 202 youth using AID systems. Low bolus frequency was defined as ≤3.0 boluses per day over 90 days. Propensity score matching paired 98 youth and eliminated baseline differences between groups, except for time spent in AID mode.

After matching, time in AID mode remained higher in one system at 80.0% compared with 64.0% in the comparator system (P = 0.01). User-initiated bolus frequency did not differ between groups and averaged 2.2 boluses per day. Adjusted TIR was higher at 54.9% compared with 46.9%, representing an absolute difference of 8.0% (P = 0.002).

These findings show that, among youth with low bolus frequency, greater time spent in AID mode was associated with higher TIR.

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Key highlights
  • Adjusted time in range (TIR) was 8.0% higher with one automated insulin delivery system compared with another in youth with low bolus frequency.
  • User-initiated bolus frequency was similar between groups at 2.2 boluses per day.
  • Greater time spent in automated insulin delivery mode was observed with the higher-performing system.
Source

Chatty P, Gera S, Rearson A, et al. Effect of Low Bolus Frequency on Automated Insulin Delivery System Performance in Youth With Type 1 Diabetes. Diabetes Care. Published online December 11, 2025. doi:10.2337/dc25-2082

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Automated Insulin Delivery Performance Varies in Youth With Low Bolus Frequency
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Short Description

Among youth delivering ≤3 daily boluses, differences in automated insulin delivery performance were associated with higher glucose time in range

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