A recent study published in Medicina Clínica highlighted the association of Diabetes ketoacidosis (DKA) in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D) in the population of Spain.
The study aimed to determine the differences in DKA between patients with type 1 and type 2 diabetes mellitus.
A total of 249 patients were included in the study. Between 2010 and 2024, all cases of DKA in a Spanish tertiary hospital were included. To identify differences between DKA in T2D and T1D, clinical and laboratory variables were collected. To evaluate 30-day mortality following a DKA event, logistic regression models were used.
It was found that 89 patients had type 2 diabetes (T2D), while 160 patients had type 1 diabetes (T1D). The T2D group (12.5% vs. 3.2%, p = 0.005) had a higher number of cardiovascular events, despite having a favorable blood gas profile, higher bicarbonate levels, and a higher pH, as well as lower ketone body concentrations (p < 0.05). In the T2D group, the 30-day mortality rate was 13.5%, while in the T1D group, it was 1.3%. Cardiovascular events, higher urea levels, and lower Glasgow Coma Scale scores were identified by logistic regression models.
Featured
Off
Page Content
#ffffff
Anonymous user
On
Authenticated user
On
Premium
On
Paid / Sponsored
On
Key highlights
- A higher 30-day mortality rate was reported in T2D patients with DKA (13.5%) compared to T1D patients (1.3%).
- The T2D group had more cardiovascular events (12.5% vs. 3.2%) and milder biochemical profiles (higher pH, bicarbonate).
- Lower GCS scores, increased urea, and cardiovascular events were the independent risk factors for DKA mortality.
Source
Tapia Sanchiz MS, Navas Moreno V, Lopez Ruano M, et al. Clinical and prognostic differences in diabetic ketoacidosis between type 2 and type 1 diabetes. Diferencias clínicas y pronósticas de la cetoacidosis diabética en diabetes tipo 2 comparado con el tipo 1. Med Clin (Barc). 2025;165(1):106973. doi:10.1016/j.medcli.2025.106973
Thumbnail
Speciality
Currency
Sub Speciality
Sub Sub Speciality
Short Description
The study highlighted the association of Diabetes ketoacidosis (DKA) in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D).
User Segments
Release Date
Featured Order
0
Is Paid
0