Indian breakfasts like upma or poha often spike blood sugar in diabetes. A new study published in the Diabetes Therapy tests swapping part of them with diabetes-specific protein supplement (DSPS). Results show real promise for daily control.
Study Design and Participants
This randomized, controlled, open-label crossover trial included 42 people with type 2 diabetes mellitus. They ate test breakfast (DSPS in 200 ml milk plus reduced upma/poha) or control (full upma/poha) for 5 days each. A 3-day washout separated phases. Labs checked postprandial glucose and insulin at 0, 30, 60, 90, 120, 150, and 180 min.
Sharp Drop in Glucose Excursions
Glucose incremental AUC0–3h fell 59% with test breakfast versus control. Delta peak glucose (ΔCmax) dropped 46%. Insulin iAUC0–3h and ΔCmax showed no big changes. No gut issues or adverse events occurred.
Real-World Gains in Home Use
During home testing, protein intake rose by 8.8 g with DSPS. Mean amplitude of glycemic excursions (MAGE) dropped significantly via CGM. Macronutrients balanced better overall. Participants liked the DSPS well.
Practical Tool for Glycemic Management
DSPS fits easily into routines for T2DM patients. It curbs spikes, adds protein, and steadies glucose without extra insulin demand. This supports its role in everyday care.
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Key highlights
- DSPS partial replacement reduces postprandial glucose iAUC0–3h by 59% and ΔCmax by 46% versus traditional Indian breakfast.
- Insulin response shows no significant change in iAUC0–3h or ΔCmax with DSPS use.
- Home use of DSPS increases daily protein intake by 8.8 g in T2DM patients.
- DSPS lowers glycemic variability, with significant reduction in mean amplitude of glycemic excursions (MAGE) per CGM.
- DSPS proves well-tolerated with no gastrointestinal or adverse events reported.
Source
Salis SS, Sanghvi A, Vora N, et al. Effect of a Diabetes-Specific Protein Supplement (DSPS) on Postprandial Glycemic Responses in Adults with Type 2 Diabetes: A Randomized Crossover Study in India. Diabetes Therapy. Published online December 24, 2025. doi: https://doi.org/10.1007/s13300-025-01834-4
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Diabetes-specific protein supplement as partial breakfast replacement slashes postprandial glucose by 59% in T2DM patients, boosts protein, and lowers variability without side effects.
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