A substantial proportion of adults with T1DM exhibit insulin resistance, which can be effectively identified using the eGDR and TyG index, according to findings published in Diabetes, Metabolism and Research Reviews.
The study included 687 adults with T1D who had been on stable insulin therapy for at least six months.

Insulin resistance was defined as eGDR < 8 or TyG index ≥ 4.68. Based on these thresholds, 25.8% of participants were insulin resistant by eGDR and 39.2% by the TyG index.

Those classified as insulin resistant showed higher HbA1c levels, poorer glyco-metabolic control, and required greater daily insulin doses. Participants identified as resistant by the TyG index also needed higher insulin doses per kilogram of body weight. Both indices were significantly associated with achieving the HbA1c ≤7% target, reinforcing their utility as practical, noninvasive tools for evaluating insulin resistance and optimizing management in adults with T1D.