‌Cardiac amyloidosis is a progressive condition with high mortality, and early identification of high-risk patients is crucial. This study, presented at the European Society of Cardiology Conference 2025, evaluated the prognostic value of Feature-Tracking cardiac magnetic resonance in 81 patients with cardiac amyloidosis, followed for a median of 38 months.

The analysis derived global longitudinal, circumferential, and radial strain values from two-dimensional cine images. An apical sparing pattern was identified in 39 percent of patients. During the observation period, 37 patients were recorded with all-cause mortality, and 42 developed acute heart failure events. Patients with global longitudinal strain values greater than minus 12.2 percent had a threefold higher risk of all-cause mortality, cardiovascular death, and acute heart failure, independent of amyloidosis subtype.

These findings highlight the utility of Feature-Tracking cardiac magnetic resonance in risk stratification. Early identification of patients at high risk allows for closer monitoring and informed management decisions, potentially improving outcomes in this vulnerable population.