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Glucagon is essential for treating severe hypoglycemia, yet prescribing rates remain low among patients at highest risk. A study published in Diabetes Spectrum evaluated glucagon prescribing patterns in a federally qualified health center (FQHC) from March 2022 to March 2023.

The retrospective chart review included 7,304 patients with diabetes; 95% had type 2 diabetes, and 61.5% were on insulin therapy. Despite this, only 4.4% had an active glucagon prescription. Among 65 patients with a history of hypoglycemia, 80% were receiving high-risk glucose-lowering medications, but just 13.8% were prescribed glucagon.

The findings underscore a significant gap between American Diabetes Association (ADA) guideline recommendations and real-world practice, particularly in FQHC settings where socioeconomic barriers may further limit access. Enhanced provider education and targeted interventions are needed to improve glucagon prescribing and hypoglycemia preparedness in high-risk populations.

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Key highlights
  • Only 4.4% of high-risk patients had an active glucagon prescription.
  • Most individuals with documented hypoglycemia and on high-risk medications did not receive glucagon.
  • Patients with type 1 diabetes were more likely to be prescribed glucagon than those with type 2 diabetes (P = 0.002).
     
Source

Arellano BA, Lin KP, Park C, et al. Observations of glucagon prescribing patterns for high-risk people with diabetes within a federally qualified health center. Diabetes Spectr. 2025;38(4):ds250044. doi:10.2337/ds25-0044

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Glucagon Remains Underprescribed Among High-Risk Patients With Diabetes
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Short Description

In a federally qualified health center, few patients at risk for hypoglycemia received glucagon despite guideline recommendations

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