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Postprandial glucose excursions detected by CGM may offer valuable insight into glycemic improvement potential among adults with type 1 diabetes, according to a study published in Diabetes Research and Clinical Practice.

In this prospective cohort, 287 adults with type 1 diabetes used CGM for at least 90 days through the Korean National Home Care Pilot Program at Samsung Medical Center. Glucose excursions were classified using the Glucose Rate Increase Detector (GRID) algorithm based on peak glucose thresholds (≥ 7.8, ≥ 10.0, and ≥ 13.9 mmol/L) and time-to-peak intervals.

A higher frequency of excursions with very high peaks (≥ 13.9 mmol/L) showed the strongest inverse association with time in range (TIR), independent of time-to-peak. Participants with four or more high-peak excursions at baseline had significantly greater odds of achieving > 5 % TIR improvement after CGM education, regardless of baseline HbA1c.

These findings establish GRID-defined postprandial peaks as simple, reproducible CGM-derived indicators that can guide personalized diabetes interventions and optimize glycemic management strategies.

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Key highlights
  • Frequent postprandial glucose excursions ≥ 13.9 mmol/L show a strong inverse association with time in range (TIR).
  • Longer time-to-peak excursions are also linked to reduced TIR, underscoring the significance of postprandial dynamics.
  • Adults with ≥ 4 high-peak excursions had greater odds of achieving > 5 % TIR improvement following continuous glucose monitoring (CGM) education, independent of HbA1c.
  • Postprandial glucose spikes identified by CGM may serve as practical markers for guiding personalized glycemic management in type 1 diabetes.
Source

Park SH, Oh R, Kim S, et al. Identification of clinically meaningful automatically detected postprandial glucose excursions in individuals with type 1 diabetes using personal continuous glucose monitoring. Diabetes Res Clin Pract. Published online October 19, 2025. doi:10.1016/j.diabres.2025.112951

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High Postprandial Glucose Peaks Predict Glycemic Improvement in Type 1 Diabetes
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Short Description

Analysis using the Glucose Rate Increase Detector algorithm identifies CGM-derived markers that predict time-in-range improvement

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