A new cohort study published in the Acta Diabetologica has found that a higher estimated glucose disposal rate (eGDR) is significantly associated with reduced risk of kidney function decline in people with diabetes and prediabetes, but not in those with normal glucose tolerance (NGT). These findings offer new insights into personalized renal risk assessment based on metabolic profiles.

The study followed 5,069 participants for up to five years. The researchers assessed changes in kidney function and evaluated the association between baseline eGDR levels and outcomes. One-hundred-sixteen individuals (2.30%) had reduced kidney function during the study period.

After confounder adjustment, individuals in the highest eGDR quartile (Q4) had markedly lower odds of experiencing kidney function reduction compared to those in the lowest quartile (Q1). This inverse relationship was sustained across the total population (HR 0.13,), and in participants with prediabetes (HR 0.11) and diabetes (HR 0.06). However, no such association was observed among those with normal glucose tolerance.