Inflammatory bowel disease (IBD) is linked to systemic inflammation and elevated cardiovascular risk; however, its effect on short-term outcomes during hospitalization for acute myocardial infarction (MI) has not been clearly defined. A nationwide retrospective cohort study published in Future of Cardiology analyzed National Inpatient Sample data to compare in-hospital outcomes among patients admitted with acute MI with and without IBD.

Data from the National Inpatient Sample (2016-2022) were analyzed to identify 1,456,940 MI hospitalizations, including 7,430 patients with IBD. Multivariable logistic regression assessed associations between IBD and post-MI complications, reported as adjusted odds ratios (aORs) with 95% confidence intervals (CIs).

After adjustment, IBD was associated with higher in-hospital mortality (aOR 3.32; 95% CI 3.18-3.47; p<0.0001). IBD was also associated with increased odds of left ventricular rupture (aOR 4.46; 95% CI 3.16-6.28; p<0.0001), left ventricular aneurysm (aOR 1.93; 95% CI 1.61-2.31; p < 0.0001), acute mitral regurgitation (aOR 9.80; 95% CI 6.81-14.10; p < 0.0001), and stent restenosis (aOR 1.16; 95% CI 1.07-1.26; p = 0.0002). Additionally, IBD was associated with longer hospital stay (coefficient 2.13 days; 95% CI 2.03-2.23; p < 0.0001) and higher total hospital charges.

In this nationwide analysis, IBD was associated with increased mortality, mechanical complications, and resource utilization during MI hospitalization.