Hybrid closed loop therapy improved glucose control in very young children with type 1 diabetes mellitus (T1D). Published in Diabetes Technology and Therapeutics, the article reports glycemic outcomes across a full year of hybrid closed loop use.

The study included children under six years of age with T1D who used the hybrid closed loop system. Data from before hybrid closed loop initiation and at one, three, nine, and twelve months were compared with linear mixed models. The first mention of type 1 diabetes mellitus (T1D) appears here.

Time in range increased by eleven percent at one month mark. Time above range decreased by thirteen percent. These gains persisted through twelve months with the largest improvements overnight. Hypoglycemia metrics remained stable across the study period. Hourly analysis showed a late morning peak in hypoglycemia risk, with time below range reaching eleven percent between eleven in the morning and one in the afternoon. This pattern remained evident at the one year mark.

These findings show that hybrid closed loop therapy improves glycemic stability in very young children with type 1 diabetes mellitus and highlight the need for targeted adjustments during late morning hours.