Adults with type 1 diabetes experienced substantial improvements in glycemic control after starting hybrid closed-loop insulin delivery. The findings were presented at the European Society of Cardiology Conference 2025.

Patients, aged 44 ± 12 years on average, with a mean diabetes duration of 19 ± 13 years, were enrolled across 12 specialized diabetes centers in Belgium. Most of these were already using insulin pumps (78%) and continuous glucose monitoring (95%).

Time in range (glucose 3.9–10.0 mmol/L) increased from 57% at baseline to 69% at 12 months. The proportion of participants achieving the recommended target of >70% TIR rose from 18% to 47%. HbA1c fell from 7.6% to 7.0%, while time spent in hypoglycemia decreased from 3.7% to 1.4%.

Patient-reported outcomes also improved, including reduced fear of hypoglycemia, better diabetes-related quality of life scores, and higher treatment satisfaction. Severe hypoglycemic events dropped markedly from 28.5 to 1.7 events per 100 person-years. The cumulative dropout rate was 9.6%, mainly due to technology-related burden.

These results demonstrate that hybrid closed-loop systems can enhance glycemic outcomes, minimize hypoglycemia, and improve quality of life in adults with type 1 diabetes over one year.