Hybrid closed-loop (HCL) insulin delivery systems have demonstrated glycemic benefits in people with type 1 diabetes (T1DM). This qualitative study published in Journal of Diabetes Research examined user and partner perspectives from the NHS England HCL pilot to better understand the psychosocial and practical impact of HCL therapy.

Fourteen people living with T1D (PWT1Ds) and 12 partners who participated in the pilot completed semistructured interviews conducted via telephone or video call. Interview topics included glucose management, daily life, time spent managing diabetes, and challenges with the HCL system. Interviews were audio-recorded, transcribed, and analyzed using inductive thematic analysis. Findings were subsequently mapped onto an adapted Optimal Health Wheel framework comprising emotional, intellectual, social, and physical domains.

Ten subthemes emerged: knowledge and prior experience, building trust, impact on physical health, impact on mental wellbeing, time and trial-and-error learning, diabetes management, lifestyle, relationships, work, and support needs. Participants reported perceived physiological and psychosocial benefits, including improved glucose management and reduced daily burden. Technical issues and initial learning hurdles were reported, though prior experience and structured learning facilitated adaptation.

Participants and partners endorsed HCL use despite early challenges. Appropriate training and access to support were identified as important for future implementation. These findings highlight the potential of HCL systems in T1DM treatment.