Hypertension management in adults over 75 lacks clear data on CVD risk without prior events. This nationwide study published in the European Journal of Preventive Cardiology assessed how five BP statuses link to new stroke or myocardial infarction. It used real-world data to guide elderly care decisions.
Methods Leverage Massive Korean Database
Researchers drew from K-NHIS database for 869,781 people aged ≥75 (mean 78.49 years, 41.7% men) checked 2012-2015. They classified normal, pre-hypertension, new-onset, controlled, and uncontrolled hypertension. Fine-Gray models with death competing risk gave sub-distribution HRs. Splines checked BP nonlinear ties to CVD over mean 6.67 years.
Results Show Graded Risk by BP Status
During follow-up, 13.8% (120,353) had incident CVD. Vs. normal BP, risks rose: pre-HTN HR 1.13 (95% CI 1.11-1.16), new-onset 1.29 (1.26-1.33), controlled 1.21 (1.18-1.23), uncontrolled 1.33 (1.30-1.36). Patterns held for stroke and MI subtypes.
Conclusions Stress Tailored Elderly BP Control
Even controlled hypertension raised CVD risk in those ≥75, peaking with uncontrolled cases. Stroke risk climbed steadily with systolic BP, while MI showed U-shaped diastolic ties. These patterns urge optimized BP strategies for late-life prevention trials.