L-Wave Needs Better Understanding
Doctors see L-waves on mitral inflow Doppler often. Their meaning stays unclear in patients without heart failure. This study published in the Journal of Indian College of Cardiology compares L-wave traits to other inflow measures by ejection fraction type.
Echo Parameters Fill Out Picture
Researchers studied 112 patients who showed clear L-waves on echo. They measured E, A, e', a', L, and L' velocities carefully. They also checked R-E, R-e', E-L, e'-L' times plus isovolumic relaxation time. Deceleration times came for E and L waves too. Ratios included E/A, E/L, and E/e'. Left ventricular EF percentage and left atrial volume index rounded out the data.
Preserved EF Dominates Cohort
Group 1 made up 81% with EF ≥50%. Group 2 showed reduced EF clearly. Group 2 had larger left atrial volume index at 40 ± 17.4 mL/m². Their L-wave deceleration time stretched to 230 ± 101 ms. R-E time hit 450 ± 65 ms. All differences carried p<0.05 significance.
Correlations Split by EF Type
L-wave velocity linked positively to E-wave velocity across groups. It showed negative ties to E-L and corrected E to L time everywhere. In reduced EF cases, L-wave deceleration time correlated positively with left atrial volume index at r=0.6 with p=0.04. Preserved EF cases showed L-wave velocity dropping with L-wave deceleration time at r=-0.4 and p=0.01. It also fell with R-R at r=-0.3 and p=0.007 plus R-E at r=-5 with p<0.001. L-wave deceleration time rose with E-L at r=0.4 and p=0.005 in preserved EF.
L-Wave Flags Filling Pressures
Mitral L-wave helps grade diastolic function and pressures well. Short E-L time strengthens this link. L-wave deceleration time patterns change by EF type. Reduced EF links it to atrial size. Preserved EF ties it to timing measures. Fast heart rates bring pathological L-waves.
Use L-Wave in Daily Echoes
Add L-wave measures to diastolic assessment now. Match findings to EF status for best read.
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Key highlights
- Researchers examined 112 patients displaying prominent L-waves and measured comprehensive mitral inflow parameters including E, A, e', a', L, L' velocities plus multiple timing intervals and ratios.
- Group 1 comprising 81% of patients maintained preserved ejection fraction ≥50% while Group 2 demonstrated significantly larger left atrial volume index at 40 ± 17.4 mL/m² with p<0.05.
- L-wave velocity exhibited positive correlation with E-wave velocity but negative correlations with E-L and corrected E to L time across all patient groups studied comprehensively.
- In reduced ejection fraction patients, L-wave deceleration time showed positive correlation with left atrial volume index at r=0.6 with statistical significance at p=0.04.
- Preserved ejection fraction patients displayed L-wave velocity negatively correlating with L-wave deceleration time (r=-0.4, p=0.01), R-R (r=-0.3, p=0.007), and R-E (r=-5, p<0.001) while L-wave deceleration time positively correlated with E-L (r=0.4, p=0.005).
Source
Ibtesam Ibrahim El-Dosouky, Shaimaa Wageeh, Hisham Samir Roshdy, Zein G. Mitral L-wave: The Missed Piece of Puzzle on Evaluation of Left Ventricular Diastolic Function across Different Ejection Fraction Phenotypes. Journal of Indian College of Cardiology. 2025;15(4):132-136. doi: https://doi.org/10.4103/jicc.jicc_41_24
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Short Description
Study of 112 patients with prominent L-waves shows preserved EF group (81%) has distinct correlations vs reduced EF, linking LDT to LAVI (r=0.6) and E-L time patterns.
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