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A recent study published in BMC Endocrine Disorders highlighted the relationship between vitamin D levels and insulin resistance. 

The study aimed to determine the association between both in type 2 diabetes patients of Sana’a city.
A total of 50 participants were included. Patients were divided into a treatment group and a control group. With patients aged 22 to 55 years, an interview was conducted to gather daily habits, clinical characteristics, personal information, and dietary practices. HbA1c, fasting blood glucose, insulin, BMI, Vitamin D, HOMA-β, and HOMA-IR were measured. For data analysis, a statistical software package was used. 

In the patient group, 40% of the patients had vitamin D deficiency, compared to healthy individuals ( 20%).

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Key highlights
  • 40% of T2DM patients had vitamin D deficiency, double that of healthy controls (20%).
  • The study assessed clinical and lifestyle factors along with metabolic parameters.
  • Findings suggest a significant association between low vitamin D and insulin resistance in T2DM.
Source

Al-Shami, A.S., Alzumor, M., Aladhal, A. et al. Association between vitamin D level and insulin resistance among patients with type 2 diabetes mellitus in Sana’a City. BMC Endocr Disord 25, 152 (2025). https://doi.org/10.1186/s12902-025-01972-7 

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Vitamin D and T2DM
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The study reported a significant association between low vitamin D and insulin resistance in T2DM.

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