A recent study published in Frontiers in Nutrition highlighted the association of estimated glucose disposal rate (eGDR) with Metabolic dysfunction-associated steatotic liver disease (MASLD) and dyslipidemia.
The study aimed to determine the relationship between eGDR and MASLD risk for assessment of insulin resistance.
By using CAP more than 285 dB/m, the MASLD was diagnosed. A total of 3957 patients were selected using NHANES 2017-2018 data. From hypertension, waist circumference, and HbA1c, the eGDR was calculated.
Higher MASLD risk and increased CAP values were predicted by lower eGDR. Correlation with unfavorable lipid profiles (lower HDL, higher triglycerides) was also found. Consistent association across sex, diabetes status, and age was seen by subgroup analysis.
While association of eGDR and MASLD was found with high-density lipoprotein cholesterol HDL, uric acid to HDL ratio (UHR), triglyceride (TG), relative fat mass (RFM), and visceral adiposity index (VAI), with respective proportions of 6.79%, 12.9%, 6.53%, 61.09%, and 9.85% by mediation analysis.
• Lower eGDR was significantly associated with increased risk of MASLD and elevated liver fat (CAP >285 dB/m) in 3,957 U.S. adults.
• Unfavorable lipid profiles, including lower HDL and higher triglycerides, were correlated with
• Mediation analysis showed the strongest indirect effect through relative fat mass (61.09%) and visceral adiposity index (9.85%).
Liu D, Lv X, Li W, et al. Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and dyslipidemia in US adults: A cross-sectional study. Front Nutr. 12:1621074. doi:10.3389/FNUT.2025.1621074
There is an association of estimated glucose disposal rate (eGDR) with Metabolic dysfunction-associated steatotic liver disease (MASLD) and dyslipidemia