Meta-Analysis Reveals Site-Dependent Right Ventricular Functional Changes After RV Pacing

Tags

Featured

Off

Page Content

#ffffff

Dual-chamber pacemakers can harm left ventricle function at high burden. Right ventricular (RV) pacing's effect on RV remodeling needs study. In a recent study published in the Arrythmia and Electrophysiology Review, the researchers conducted a systematic review and meta-analysis on RV function changes post-RV pacing.

Following PRISMA guidelines, searches covered Embase, PubMed, SCOPUS to March 2024. Studies reported RV parameters: RVEF, sPAP, TAPSE, RV volume, S′, FAC, RIMP, tricuspid regurgitation. Eighteen studies with 1,220 patients qualified. Pooled mean differences assessed pacing effects. Subgroup analyses checked pacing site and duration.

RV pacing tied to S′ drop (−1.35 cm/s, 95% CI −2.36 to −0.34, p=0.009). RVEF fell non-significantly (2.28%, p=0.21); TAPSE (−0.04 cm, p=0.57), RIMP (−0.07, p=0.52), FAC (−0.12%, p=0.95), sPAP (3.73 mmHg, p=0.46). Heterogeneity high (I²>89%). Pacing site mattered: apical pacing hurt TAPSE, S′, FAC, sPAP most; LBBAP showed least impact. Duration affected RIMP (p=0.01).

In this meta-analysis, RV pacing associated with significant S′ decline and variable effects on other RV measures. Apical pacing linked to worse outcomes; LBBAP better. High heterogeneity noted, suggesting further covariate studies.

Anonymous user

Authenticated user

Premium

Paid / Sponsored

Key highlights

RV pacing significantly reduced S′ (−1.35 cm/s, 95% CI −2.36 to −0.34, p=0.009) across 18 studies with 1,220 patients.
Non-significant changes seen in RVEF (2.28%, p=0.21), TAPSE (−0.04 cm, p=0.57), and RIMP (−0.07, p=0.52).
Apical pacing associated with greatest negative impact on TAPSE, S′, FAC, and sPAP versus other sites.
LBBAP showed least detrimental effects, particularly on sPAP, in subgroup analyses.
High heterogeneity (I²>89%) underscores need for studies on pacing site and duration effects.

Source

DeAngelo S, Aryal B, Haghshomar M, et al. Impact of Right Ventricular Pacing Sites on Right Ventricular Function: Systematic Review and Meta-analysis, Arrhythm Electrophysiol Rev. 2026;15:e02. doi: 10.15420/aer.2025.17

Thumbnail

Speciality

Cardiology

Currency

INR

Sub Speciality

Therapeutic Modality

Investigation Modality

Sub Sub Speciality

Interventional Cardiology

Implantable Devices

Investigation and Imaging

Short Description

Meta-analysis of 18 studies (1,220 patients) links RV pacing to significant S′ reduction (−1.35 cm/s, 95% CI −2.36 to −0.34, p=0.009); apical pacing worsens outcomes vs left bundle branch area pacing (LBBAP).

User Segments

Release Date

Mon, 02/09/2026 - 08:49

Featured Order

Is Paid

Send Notification

Off