A study published in The American Journal of Cardiology compared clinical and hemodynamic outcomes among three contemporary transcatheter valve types in 1,049 patients with severe symptomatic aortic stenosis. Participants received a supra-annular self-expanding, intra-annular self-expanding, or balloon-expandable transcatheter valve. Women accounted for 81% of the supra-annular group, 59% of the intra-annular group, and 26% of the balloon-expandable group.

The need for post-procedure permanent pacemaker implantation was lower with the supra-annular self-expanding valve than with the intra-annular design and similar to the balloon-expandable valve. Paravalvular leak of moderate or greater severity occurred at comparable rates between the two self-expanding valves but was lower with the balloon-expandable system.

Although one valve model has been withdrawn from clinical use, these findings confirm the reliability of current transcatheter valve technologies and highlight the importance of individualized device selection and continued design refinement to improve TAVR outcomes.