Can targeted dietary strategies reverse the course of type 2 diabetes (T2DM)? A mini review published in Frontiers in Clinical Diabetes and Healthcare examines current evidence supporting nutrition-based approaches aimed at achieving remission of T2DM.

The review synthesizes data from studies evaluating structured dietary interventions, including low-energy diets, the Mediterranean dietary pattern, ketogenic diets, and time-restricted eating. These approaches were analyzed in relation to glycemic outcomes and remission, with particular emphasis on reductions in ectopic fat and improvements in insulin sensitivity. Remission was reported more frequently in individuals with a shorter duration of diabetes, more favorable baseline glycemic status, and significant, sustained weight loss, especially when visceral and hepatic fat were reduced.

Beyond weight reduction, the review highlights the potential influence of meal timing, macronutrient composition, and adherence on glycemic outcomes. The findings suggest that nutrition-based remission represents a clinically relevant therapeutic objective, while highlighting the need for long-term randomized studies focused on remission outcomes and personalized dietary strategies.