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Pregnancy appears to influence long-term outcomes in women with type 1 diabetes. These results from the Finnish Diabetic Nephropathy Study were presented at the European Association for the Study of Diabetes (EASD) 2025.

The analysis included 2,487 women with type 1 diabetes, grouped by parity: none (41.1%), one (23.8%), two (24.4%), and three or more pregnancies (10.7%). Data on diabetic complications and mortality were retrieved from national registries through 2020, with a mean follow-up age of 53.8 years. Subgroup analyses in women aged ≥45 years confirmed the robustness of the findings.

Multiparous women demonstrated significantly lower odds of cardiovascular events, kidney replacement therapy, and death compared with nulliparous women. Those with one pregnancy showed reduced risks of heart failure and mortality but not other complications.

The findings suggest that pregnancy may encourage tighter glucose management, contributing to long-term benefits. These results provide clinically useful context for family planning discussions with women living with type 1 diabetes.
 

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Key highlights
  • Multiparous women with type 1 diabetes had lower risk of cardiovascular events, kidney complications, and mortality.
  • Nulliparous women showed higher rates of heart failure and death compared with women who had pregnancies.
  • Results support considering parity as a factor in long-term risk assessment and family planning discussions.
Source

Rimpeläinen K, Jansson Sigfrids E, Groop PH, et al. Higher parity is associated with lower likelihood of diabetic complications and mortality in women with type 1 diabetes. Presented at: 61st EASD Annual Meeting of the European Association for the Study of Diabetes; September 15-19, 2025; Vienna, Austria. Diabetologia. 2025:85. https://link.springer.com/article/10.1007/s00125-025-06497-1#Sec16 

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Parity Linked to Lower Risk of Complications in Type 1 Diabetes
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Findings from the Finnish Diabetic Nephropathy Study presented at EASD 2025 suggest multiparity protects against cardiovascular and renal outcomes.

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