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A recent study published in Diabetology International highlighted the role of hair glycation as an indicator of blood glucose control.
The study aimed to determine the potential of glycated protein in scalp hair as a marker of glycemic control. 
After obtaining informed consent from 192 participants, medical history, demographics, HbA1c measurements, and anthropometric measurements were collected. Researchers collected 50 strands of hair, 4 cm long, and stored them at 20 °C. Using the TBA method and a fructose calibration curve, the fructosamine concentration in the samples was determined. Using Pearson’s R, the strength of the correlation between HbA1c and fructosamine for hair samples was determined.

It was found that 56% of participants previously had diabetes. No correlation between HbA1c and fructosamine was found in samples with no reported hair treatment. When the sample mass ranged between 40 and 120 mg, a positive correlation was observed. When hair samples greater than 70 mg were used for the assay, the highest correlation, r(28) = 0.647, p = < 0.001, was observed.
 

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Key highlights

•    Glycated protein levels in scalp hair, measured via fructosamine concentration, showed potential as a marker of blood glucose control.
•    There was no association between HbA1c and hair fructosamine in untreated hair samples unless hair mass was within 40–120 mg.
•    The strongest correlation was found when hair mass exceeded 70 mg (r = 0.647, p < 0.001), supporting an optimal sample size for accurate analysis.

Source

Dhanoo, A.S., Cockburn, B.N. Glycated hair protein analysis as a noninvasive proxy for blood glucose monitoring: investigating the impact of sample mass and chemical hair treatments. Diabetol Int (2025). https://doi.org/10.1007/s13340-025-00828-8

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Skin Glycation and Diabetes
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The study examined the role of hair glycation as an indicator of blood glucose control.

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