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Doctors fixing severe aortic stenosis with valve replacement often see good short-term results. But long-term heart death and problems like heart failure readmissions worry everyone.
A new study published in the Journal of Thoracic and Cardiovascular Surgery tested a scoring tool called the Heart Failure Association Pretest assessment, Echocardiography and Natriuretic Peptide, Functional Testing, Final Etiology score (HFA-PEFF score) in 193 patients.  
All had isolated surgical aortic valve replacement between 2012 and 2017 and had good ejection fraction over 50%. Scores split patients into low (1 or less points), intermediate (2-4), and high (5 or more). Follow-up lasted 5.9 years on average. The main goal was to track heart death or bad cardiac events.
High Scores Mean Higher Trouble After Surgery
Over half the patients, 82 out of 193, or 54%, started with high scores. These patients faced much higher risks. Heart death was reported in 13 patients (6.7%). Heart failure or rhythm problems sent 22 back to hospital (11.4%). High-score patients had worse outcomes than intermediate or low ones. Stats showed clear split (log-rank P=0.003). Even after checks for age, other risks, the score stood strong. Each point upped primary endpoint risk by 47% (HR 1.47, 95% CI 1.07-2.10, P=0.023). 
Scores Can Improve—And That Helps Long-Term
Surgery often betters scores. Among high-score starters, 56% dropped to intermediate by 6 months. These patients cut primary endpoint risk a lot compared to those stuck high. No patient attained a low score. Valve fix eases pressure, improves heart filling and tests. But persistent high scores signal ongoing issues like hidden stiffness or failure signs. This predicts who needs close watch after discharge.
Easy Tool for Everyday Use in Valve Patients
HFA-PEFF uses basics: pretest odds, echo measures, blood tests like BNP, exercise tests, and final cause. For aortic stenosis cases, score pre-op. If they are high, plan echo follow-ups. Study focused on preserved EF, common in elderly valve disease.
Changes Coming to Post-Operative Care
Guidelines may add this score in the future. Low-risk patients go home with routine checks. High-risk? Early rehabilitation, BNP trends, strain imaging. Fewer readmissions and deaths.

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Key highlights
  • Over 54% of patients undergoing aortic valve replacement for severe aortic stenosis have high HFA-PEFF scores preoperatively.
  • High HFA-PEFF scores independently predict cardiovascular death and adverse cardiac events after surgery (HR 1.47).
  • Patients with high preoperative scores face significantly worse long-term outcomes compared to those with low or intermediate scores.
  • 56% of high-score patients improve to intermediate scores by 6 months post-surgery, reducing their primary endpoint risk.
  • The HFA-PEFF score provides useful prognostic information for risk stratification in preserved EF aortic stenosis patients.
Source

Ohmori T, Hiraoka A, Hamada Y, et al. Long-term prognostic value of Heart Failure Association Pretest Assessment, Echocardiography and Natriuretic Peptide, Functional Testing, Final Etiology score in patients undergoing isolated surgical aortic valve replacement for severe aortic stenosis. J Thorac Cardiovasc Surg. 2026 Jan;171(1):92-100.e2. doi: https://doi.org/10.1016/j.jtcvs.2025.06.021 

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HFA-PEFF score predicts heart death and problems after aortic valve surgery in patients with good ejection fraction. High scores (54% of cases) signal worse 6-year outcomes, but many improve post-operatively.

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