Simultaneous pancreas-kidney (SPK) transplantation normalizes glycemia in patients with diabetes and end-stage kidney disease, yet data describing continuous glucose monitoring (CGM) profiles after transplantation remain limited. A retrospective analysis published in Diabetes Therapy evaluated CGM metrics in SPK recipients before and after transplantation.

Nineteen SPK recipients were included. Fourteen patients continued CGM use after transplantation, and nine used CGM continuously during the entire study period. Within one month following transplantation, all CGM metrics improved significantly. Time-in-range increased from 54.21% before transplantation to 83.85% after transplantation. Time-in-tight-range (TITR) increased from 33.45% to 69.77% (p<0.05 for all comparisons). Glucose variability decreased significantly, and these improvements remained stable over 24 months.

Optimal graft function was associated with superior CGM outcomes, including higher TITR and lower mean amplitude of glycemic excursions (MAGE; p<0.05). However, hypoglycemia-related targets were not consistently achieved despite otherwise optimal graft performance.

These findings describe rapid and sustained improvement in CGM profiles following SPK transplantation and associations between graft function and glycemic metrics.