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Type 2 diabetes (T2DM) and depression burden public health in Mexico, with high prevalence of both. Research on their two-way relationship there is limited. An analysis published in the Journal of Diabetes checked prevalence, co-occurrence, association strength, and socio-demographic/geographic factors.

Data came from the 2022 National Health and Nutrition Survey. T2DM used self-report. Depression screened via Center for Epidemiological Studies Depression Scale. The sample represented Mexico (n=11,913). Descriptive stats and multivariate logistic regression tested bidirectional ties and factors like age, sex, education. Depressive symptoms hit 16.7%; T2DM 10.9%. T2DM participants had higher depression odds (OR 1.78, 95% CI 1.48-2.14). 

Depressed participants showed higher T2DM odds (OR 1.97, 95% CI 1.52-2.54 ages 20-59; OR 1.63, 95% CI 1.27-2.09 ages 60+). Women had over twice depression odds vs men (OR 2.14, 95% CI 1.83-2.51). Older adults (60+) faced 3.5 times higher depression odds (OR 3.53, 95% CI 3.00-4.15). Higher education (high school+) protected against both (depression OR 0.41, 95% CI 0.31-0.53; T2DM OR 0.52, 95% CI 0.37-0.74).

In this national survey, T2DM and depression associated bidirectionally, stronger in women and older adults. Higher education linked to lower risks. Cross-sectional findings highlight co-occurrence patterns, suggesting focus for future integrated studies.

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Key highlights
  • Depressive symptoms prevalence was 16.7% and T2DM 10.9% in 11,913 Mexican adults from 2022 survey.
  • T2DM associated with higher odds of depressive symptoms (OR 1.78, 95% CI 1.48-2.14).
  • Depressive symptoms linked to higher T2DM odds (OR 1.97 ages 20-59; OR 1.63 ages 60+).
  • Women showed over twice depression odds vs men (OR 2.14, 95% CI 1.83-2.51); older adults 3.5 times higher (OR 3.53).
  • Higher education protected against depression (OR 0.41) and T2DM (OR 0.52) in this representative cohort.
Source

Adhikari A, Chandrasenage D, Prinjha S, Zavala GA. Multimorbidity between Type 2 Diabetes and Depressive Symptoms in Mexico: Prevalence and Associated Factors From the Nationally Representative ENSANUT 2022 Survey. J Diabetes. 2026;18(2):e70177. doi:10.1111/1753-0407.70177

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2022 Mexican survey (n=11,913) shows 16.7% depressive symptoms, 10.9% T2DM; bidirectional link with T2DM patients at higher depression odds (OR 1.78, 95% CI 1.48-2.14) and vice versa.

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