Pregnancy care in monogenic diabetes requires careful subtype differentiation. A retrospective study from Rigshospitalet, Copenhagen, published in the Journal of Diabetes and Its Complications, assessed outcomes in 35 pregnancies among 22 women with GCK- or HNF1A-MODY, compared with 140 pregnancies in women with type 2 diabetes.

In GCK-MODY, median HbA1c remained steady between 45 and 46 mmol/mol across pregnancy, while values declined modestly in HNF1A-MODY and type 2 diabetes. Hypertensive disorders, preterm birth, and large-for-gestational-age infants were less frequent in GCK-MODY than in type 2 diabetes, though differences were not statistically significant.

These findings emphasize current treatment strategies: minimal intervention for GCK-MODY and adherence to established diabetes guidelines for HNF1A-MODY ensure favorable maternal and perinatal outcomes.