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A recent study published in Primary Care Diabetes highlighted the relationship between the mortality and clinical characteristics of diabetes. 
The study aimed to determine the characteristics and mortality in diabetes compared to non-diabetic patients.

According to diabetes status, men from the Geelong Osteoporosis study (n = 895) were categorized. A total of 105 men were sub grouped into the severe autoimmune diabetes (SAID) subgroup on the basis of islet antibody seropositivity. Using k-means clustering, the remaining men were classified. To determine differences in demographics, comorbidities, and lifestyle factors, ANOVA and chi-squared tests were used. To compare mortality over a median of 11.8 years, Cox proportional hazard models were used.

Higher mean blood pressure and cardiovascular comorbidities were seen in men with diabetes (Mild obesity-related diabetes (MOD), severe insulin-resistant diabetes (SIRD), and mild age-related diabetes (MARD)), compared to those without diabetes.  Higher mortality in unadjusted models was found to be associated with the MARD subgroup. In the SIRD subgroup, the mortality was not found to be different. However, higher mortality was seen in the MARD subgroup. 

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Key highlights
  • Among 895 men, 105 were diagnosed with diabetes, including a SAID subgroup identified via islet antibody seropositivity.
  • The remaining diabetes cases were categorized into MOD (Mild Obesity-related Diabetes), SIRD (Severe Insulin-Resistant Diabetes), and MARD (Mild Age-Related Diabetes) using k-means clustering.
  • Higher blood pressure and cardiovascular comorbidities were observed in MOD, SIRD, and MARD compared to non-diabetic participants.
Source

Harland JW, Liu ZSJ, Cukier K, et al. Clinical characteristics and mortality in novel subgroups of adult-onset diabetes in an Australian population-based cohort of men. Prim Care Diabetes. Published online July 4, 2025. https://doi.org/10.1016/j.pcd.2025.06.007 

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Study finds increased long-term mortality in men with mild age-related diabetes compared to non-diabetic counterparts.

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