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Early repeat ablation may offer a better chance at durable rhythm control in patients with recurrent atrial fibrillation. A multicenter prospective study published in Heart Rhythm found that shorter intervals between arrhythmia recurrence and repeat ablation were associated with significantly improved one-year outcomes.

The analysis included 1,144 patients treated across three hospitals in China between January 2019 and December 2022. Participants were divided into four groups based on the diagnosis-recurrence-to-ablation time (DRAT): Q1 (0–12 months, median 7 months), Q2 (13–33 months, median 23 months), Q3 (34–56 months, median 44 months), and Q4 (57 months or longer, median 82 months). The primary endpoint was freedom from atrial fibrillation or atrial tachycardia at 12 months.

At one year, freedom from recurrence was 71.0% in Q1, 61.7% in Q2, 61.6% in Q3, and 54.7% in Q4 (P < 0.001). Outcomes declined steadily as the interval increased, indicating that early ablation helps prevent persistent arrhythmia and structural remodeling.

These findings suggest that performing repeat ablation within 12 months of recurrence may enhance long-term rhythm stability and reduce relapse in patients with recurrent atrial fibrillation.

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Key highlights
  • Multicenter prospective study of 1,144 patients with recurrent atrial fibrillation from three hospitals in China.
  • Early repeat ablation within 12 months achieved 71% 12-month freedom from AF or atrial tachycardia.
  • Success rates declined steadily with longer diagnosis-to-ablation intervals.
Source

Wang S, Song Z, Guo J, et al. Repeat ablation timing for recurrent atrial fibrillation: A prospective study. Heart Rhythm. Published online November 10, 2025. doi:10.1016/j.hrthm.2025.11.012

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Timely Repeat Ablation Enhances Rhythm Control in Recurrent Atrial Fibrillation
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Shorter intervals between AF recurrence and repeat ablation yield better rhythm control

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