Hyperuricemia in uncontrolled type 2 diabetes mellitus (T2DM) may be detectable using a simple laboratory-based score. The study, published in Medicina,  assessed whether routine biochemical markers could help stratify risk among hospitalized patients with poor glycemic control.

This retrospective analysis included 253 adults with uncontrolled T2DM (HbA1c ≥7%) admitted to a tertiary center between 2022 and 2023. Patients were classified by hyperuricemia status using sex-specific uric-acid thresholds, and demographic, metabolic, and treatment features were compared. A RMRS incorporating serum urea and the TG/LDL ratio was derived and evaluated through ROC analysis.

Clinical data showed that hyperuricemic patients (n=233) had substantially higher serum urea (32.15 ± 21.21 mg/dL) than those without hyperuricemia (19.76 ± 10.02 mg/dL; p<0.001). TG/LDL values were also numerically higher (2.94 ± 6.73 vs. 1.95 ± 1.28; p=0.062). The RMRS achieved an AUC of 0.67 and differed significantly between groups (p≈1.2×10⁻⁵).

These findings suggest that combining urea with TG/LDL may offer a pragmatic early-risk tool for renal–metabolic dysfunction in uncontrolled T2DM. Although preliminary, such a score could support earlier monitoring strategies and guide intervention before complications progress.