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Choi KH, Park YH, Lee JY, et al. Efficacy and safety of clopidogrel versus aspirin monotherapy in patients at high risk of subsequent cardiovascular event after percutaneous coronary intervention (SMART-CHOICE 3): a randomised, open-label, multicentre trial. Lancet. 2025;405(10486):1252-1263. doi:10.1016/S0140-6736(25)00449-0
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SMART-CHOICE 3 compared the efficacy and safety of clopidogrel versus aspirin monotherapy beyond the standard duration of dual antiplatelet therapy (DAPT)—over 12 months for myocardial infarction (MI) and over 6 months for non-MI—in patients at high risk of recurrent ischemic events following percutaneous coronary intervention (PCI).
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