Speaker Name: Prof. Stefano Del Prato, Professor of Endocrinology and Metabolism, University of Pisa School of Medicine, Chief of the Section of Diabetes, University of Pisa, Italy.

Watch this expert session to:

• Understand the central role of β-cell dysfunction in the development and progression of T2DM.
• Recognize that β-cell impairment may begin during prediabetes, before overt hyperglycemia is diagnosed.
• Review how glucotoxicity, lipotoxicity, obesity, and genetic susceptibility contribute to progressive loss of insulin secretory capacity.
• Evaluate findings from UKPDS, VERIFY, and DiRECT supporting early insulin therapy, combination treatment, and weight reduction to improve glycemic durability or remission outcomes.
• Apply current ADA/EASD recommendations for timely insulin initiation and individualized treatment intensification in T2DM.